Tianjin University of Traditional Chinese Medicine, 88 Yuquan Road, Tianjin 300193, China, Center for Drug Reevaluation, State Food and Drug Administration, Xicheng, Beijing 100045, China, Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, 816 Zhenli Road, Tianjin 300150, China, Dongzhimen Hospital, Beijing University of Chinese Medicine, Dongcheng, Beijing 100007, China, Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China, Evidence-Based Complementary and Alternative Medicine. A handful of patients were found with abdominal distension, abdominal pain, diarrhea, rash, pruritus, and other symptoms. National Pharmacopoeia Committee. The main reason for using HSW is that patients suffer from gray hair and hair loss; this may be associated with those patients who are more likely to use HSW products, but whether patients suffering from gray hair or hair loss are prone to occurrence of liver damage associated with HSW remains to be further studied. The HSW forms of case reports are shown in Table 4; in terms of usage, all involved Chinese patent medicines are of oral formulation; the types of HSW decoction pieces used included tea, liquor, powder, and decoction. Symptoms of liver damage occur mostly a month or so after taking the medicine, mainly including jaundice, fatigue, anorexia, and yellow or tawny urine. Han X., Wu C. A., Wang W., Liu S., Wang L. Y. (PM) have been reported since 2006, which aroused widespread concern. 2020. 2020 Nov 21;12(11):729. doi: 10.3390/toxins12110729. : A Systematic Review of Case Reports and Case Series", Evidence-Based Complementary and Alternative Medicine, vol. It has also been shown to protect liver cells from damage by toxins including dry cleaning fluid. Nutrients. Damage effect of Polygonum multiflorum fractions on human normal liver cells L02 and liver cancer cells Hep Zhang Ruichen – China Journal of Chinese Materia Medica CJCMM – 2012 Cytoprotective properties of traditional Chinese medicinal herbal extracts … HSW can cause different degrees of liver injury, even need of liver transplantation (2/450), and death (6/450). The type of fo-ti typically used is red fo-ti, which is the root boiled in a liquid made with black beans. HSW causes liver toxicity and may cause liver damage in different degrees and even lead to death; most of them are much related to long-term and overdose of drugs. In case series, there is insufficient information on dose and duration of taking HSW of each patient, but some articles indicate that the majority of patients take Chinese patent medicine in accordance with the instructions. Toxins (Basel). According to case reports and case series, most of the patients had been hospitalized with jaundice, fatigue, anorexia, and yellow or tawny urine. Epub 2014 Nov 18. 2017 May 5;203:182-190. doi: 10.1016/j.jep.2017.03.046. Tinnitus The unprocessed root, kno… Fo-Ti has been found to cause acute liver damage for those taking more than 12 grams a day for 30-60 days. To fully understand the characteristics and possible factors of hepatitis associated with HSW, we conduct a comprehensive review of the relevant published literatures; we hope that our findings can provide guidance for clinical medication and scientific research and thus can help to avoid hepatitis induced by HSW in the future. Radix Polygoni Multiflori (RPM), the dry root of Polygonum multiflorum Thunb. In case series, there is insufficient information on HSW forms and usage of each patient, but it is worth noting that, in two case series, the ratio of processed HSW to raw HSW is 5 : 13 and 25 : 11, respectively [18, 22]. The duration of taking HSW of case reports. Results. Evid Based Complement Alternat Med. Epub 2018 Dec 6. The mystery of liver damage of Polygonum multiflorum Thunb., A few days ago, the International Journal of Hepatology Hepatology (liver disease, IF=14.079) published the results of the collaboration of the Chinese Medicine Research Institute of the PLA fifth medical center, Xiao Xiaohe, associate research fellow Wang Gabo team and academician of the Chinese Academy of Song, “Correlation analysis of drug-induced liver injury caused by, Y. Wang, “Clinical research of drug-induced liver injury caused by, X. Zhang, X. C. Ding, Y. Yang, P. Zhang, and F. F. Wu, “Clinical analysis of 6 patients with liver diease induced, M. Leng, “One case of acute severe liver injury caused by conventional dose Polygonum multiflorum,”, J. Q. Sheng, “Familial acute liver injury caused by, Q. H. Ye, “One case of acute toxic liver disease caused by, W. Huang, Y. N. Zhang, and R. Sun, “Experimental study on the “Dose-Time-Toxicity” relationship of acute hepatotoxicity induced by different components from, J. Yu, J. Xie, R.-H. Zhao, S.-Q. Chinese Pharmacopoeia. He, J. Jiang, and Z. Y. Xiong, “Clinical Analysis of drug-induced liver injury caused by, G. Q. Liu, “Clinical analysis of 9 cases of drug-induced liver injury by, X. H. Zhou and X. Qiu, “Clinical analysis of 11 cases of drug-induced liver injury by, H. Dong, D. Slain, J. Cheng, W. Ma, and W. Liang, “Eighteen cases of liver injury following ingestion of, J. Xu, M. R. Wang, C. L. He, Y. H. Sui, and F. Qiao, “Liver injury by peroral, S. G. Zhang, W. Yi, R. J. Hao, J. F. Peng, and G. Zhao, “Analysis of 13 cases of liver damage caused by, K. A. Jung, H. J. Min, S. S. Yoo et al., “Drug-induced liver injury: twenty five cases of acute hepatitis following ingestion of, E. Ding, “Clinical analysis on the treatment of drug-induced liver injury by, X. J. Xie, K. F. Ma, and Y. Liu, “Analysis of liver injury induced by, X. Q. Guo, “Clinical characteristics analysis of liver damage caused by, L. Y. All seven reports are of liver reactions and comprise one report of abnormal liver function, 3 reports of … Evid Based Complement Alternat Med. This site needs JavaScript to work properly. Review articles are excluded from this waiver policy. Progress in Modern Biomedicine. NIH Immune function 6. Long, “The effective mechanism of 2, 3, 5, 4′-tetrahy-droxystilbene-2-O-, Y. Y. Yang, H. S. Wang, and S. B. Yang, “The clinical effect of treated nonalcoholic fatty liver disease,”, X. Y. Wei, J. K. Zhang, Y. H. Luo, S. B. Chen, and J. L. Sun, “Antagonistic effect of, C. L. Ge and Y. Liu, “Polysaccharide from, H. N. Kim, Y. R. Kim, J. Y. Jang et al., “Neuroprotective effects of, L. Liu, L. Li, L. Zhao, L. Zhang, Y.-L. Li, and C.-F. Ye, “Effects of 2,3,5,4′-tetrahydroxystilbene-2-O-, J. Yu, J. Xie, X.-J. The case series that reported the average length of hospitalization was about four weeks [18, 21, 23, 28–31]. According to the U.S. National Library of Medicine, several people have experienced acute liver damage after taking fo-ti. While there are many HSW-containing products, the most well-known product is like Shou-Wu-Pian, which is usually consumed as an antiaging product, or as a tonic for dizziness with tinnitus, and also appears to be efficacious in the treatment of premature greying of hair, lumbago, spermatorrhea, leucorrhea, and constipation. Please enable it to take advantage of the complete set of features! https://selfhacked.com/blog/fo-ti-polygonum-multiflorum-miracle-herb-death-trap On the other side, emodin also serves as a liver-protective agent. -. Traditional herbalism uses the roots of the plant, either unprocessed or boiled with black beans, for … This study aimed to identify the genetic basis of susceptibility to PM‐drug‐induced liver injury (PM‐DILI) and to develop biological markers for predicting the risk of PM‐DILI in humans. The roots of Polygonum multiflorum (PM) (He Shou Wu in Chinese) are one of the most commonly used tonic traditional Chinese medicines (TCMs) in China. 2017. Gout. Evid Based Complement Alternat Med. (He Shou Wu in Chinese pinyin, hereinafter referred to as HSW) is the root of Polygonum multiflorum, a member of Polygonaceae. Conclusion. Evid Based Complement Alternat Med. He Shou Wu benefits the health of your kidney and liver and supports the … Epub 2017 Mar 29. The full texts of potentially relevant articles were retrieved for detailed assessment. Conclusion. Polygonum multiflorum Thunb. With the wide application, liver damage associated with HSW has been reported in China, Korea, Japan, Britain, Italy, Australia, and other countries [14, 15]. To summarize the characteristics and analysis of relevant factors and to give references for prevention and further study of liver damage associated with Polygonum multiflorum Thunb. The two forms have different properties: the raw HSW is used for detoxification, eliminating carbuncle, preventing malaria, and relaxing bowel, whereas the processed HSW is used for nourishing liver and kidney, supplementing essence and blood, blackening hair, strengthening bones and muscles, eliminating dampness, and reducing lipid [2]. Arthritis. In 72 cases of case reports, patients ranged in age from 5 to 78 years, with a median of 36.5. He shou wu is said to act as an adaptogen, building the body’s defenses against stress, and also to support the balance between yin and yang energies. This review covers a total of 450 cases in 76 articles. The search terms included Polygonum multiflorum, radix polygoni multiflori, He Shou Wu, liver injury, liver damage, liver diseases, hepatitis, and liver failure in English or Chinese. In case series, seven articles reported 53 (53/138, 38.4%) cases with liver damage related to HSW many times [17, 21, 27, 29–31]. (HSW), we provide a systematic review of case reports and case series about liver damage associated with HSW. (Fam. Many cases of liver damage associated with HSW had been reported worldwide; HSW has liver toxicity and may cause different degrees of liver damage. Two authors (Xiang Lei and Jing Chen) independently examined the titles and abstracts of all papers found through the search to determine if they fulfilled the inclusion criteria outlined above. Because HSW induced liver injury is not a specific diagnostic method and some cases included in this review also take other drugs or herbal medicines, so considering the doctors experience, medical technology, and other limiting factors may not show all liver injury is caused by HSW. Chen Q. T., Zhuo L. H., Xu W., Huang Z. H., Qiu X. H. Content changes of 5 components in Polygohum muhiflorum during processing. Liver Damage Associated with Polygonum multiflorum Thunb. Chinese Archives of Traditional Chinese Medicine. ACS Omega. HSW types included raw and processed HSW decoction pieces and many Chinese patent medicines that contain HSW. This would be a hand full of our capsules per day. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. 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